Leiden University Scholarly Publications

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Otter, R.; Klinker, K.; Spitzer, D.; Schinnerer, M.; Barz, M.; Besenius, P. (2018)

Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell

Article / Letter to editor
We report the synthesis of ABA' triblock peptide-polysarcosine-peptide conjugates featuring two complementary phenylalanine-histidine pentapeptide strands A/A'. These sequences encode for antiparallel beta-sheet formation into folded conjugates, which promote the self-assembly into polysarcosine-shielded core-shell nanorods. These do not cause aggregation of serum proteins in human blood plasma underlining an enhanced stability.
All authors
Otter, R.; Klinker, K.; Spitzer, D.; Schinnerer, M.; Barz, M.; Besenius, P.
Date
2018-01-14
Volume
54
Issue
4
Pages
401 - 404
DOI
doi:10.1039/c7cc08127h