The route of early T cell development: crosstalk between epigenetic and transcription factors

Chiara, V. della; Daxinger, L.; Staal, F.J.T. (2021)

Article / Letter to editor

Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphocytes. Lineage-specific transcription factors are key drivers of T cell specification and act in conjunction with epigenetic regulators that have also been elucidated as crucial players in the establishment of regulatory networks necessary for proper T cell development. In this review, we summarize the activity of transcription factors and epigenetic regulators that together orchestrate the intricacies of early T cell development with a focus on regulation of T cell lineage commitment.

• T cell development
• T cell commitment
• transcription factors
• epigenetic regulators
• chromatin modifiers
• Tcf1
• Bcl11b
• Dnmt3
• Polycomb genes

• All authors: Chiara, V. della; Daxinger, L.; Staal, F.J.T.
• Date: 2021-05-01
• Journal: Cells
• Volume: 10
• Issue: 5
• DOI: doi:10.3390/cells10051074
• Link: https://www.mdpi.com/2073-4409/10/5/1074/pdf