Platelet Acetyl-CoA Carboxylase Phosphorylation A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients

Kautbally, S.; Lepropre, S.; Onselaer, M.B.; Rigoleur, A. le; Ginion, A.; Ravenstein, C.D. de; ... ; Beauloye, C. (2019)

Article / Letter to editor

Adenosine monophosphate-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK-induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK-induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

• AMPK
• acetyl-CoA carboxylase
• coronary artery disease
• lipidomics
• platelet

• All authors: Kautbally, S.; Lepropre, S.; Onselaer, M.B.; Rigoleur, A. le; Ginion, A.; Ravenstein, C.D. de; Ambroise, J.; Boudjeltia, K.Z.; Octave, M.; Wera, O.; Hego, A.; Pincemail, J.; Cheramy-Bien, J.P.; Huby, T.; Giera, M.; Gerber, B.; Pouleur, A.C.; Guigas, B.; Vanoverschelde, J.L.; Kefer, J.; Bertrand, L.; Oury, C.; Horman, S.; Beauloye, C.
• Date: 2019-09-01
• Journal: JACC-BASIC TO TRANSLATIONAL SCIENCE
• Volume: 4
• Issue: 5
• Pages: 596 - 610
• DOI: doi:10.1016/j.jacbts.2019.04.005