Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study

Menditto, E.; Costa, E.; Midao, L.; Bosnic-Anticevich, S.; Novellino, E.; Bialek, S.; ... ; Laune (2019)

Article / Letter to editor

Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries.Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App.Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach.Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users.Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.

• adherence
• mHealth
• mobile technology
• observational study
• rhinitis
• treatment

• All authors: Menditto, E.; Costa, E.; Midao, L.; Bosnic-Anticevich, S.; Novellino, E.; Bialek, S.; Briedis, V.; Mair, A.; Rajabian-Soderlund, R.; Arnavielhe, S.; Bedbrook, A.; Czarlewski, W.; Annesi-Maesano, I.; Anto, J.M.; Devillier, P.; Vries, G. de; Keil, T.; Sheikh, A.; Orlando, V.; Larenas-Linnemann, D.; Cecchi, L.; Feo, G. de; Illario, M.; Stellato, C.; Fonseca, J.; Malva, J.; Morais-Almeida, M.; Pereira, A.M.; Todo-Bom, A.M.; Kvedariene, V.; Valiulis, A.; Bergmann, K.C.; Klimek, L.; Mosges, R.; Pfaar, O.; Zuberbier, T.; Cardona, V.; Mullol, J.; Papadopoulos, N.G.; Prokopakis, E.P.; Bewick, M.; Ryan, D.; Roller-Wirnsberger, R.E.; Tomazic, P.V.; Cruz, A.A.; Kuna, P.; Samolinski, B.; Fokkens, W.J.; Reitsma, S.; Bosse, I.; Fontaine, J.F.; Laune, D.; Haahtela, T.; Toppila-Salmi, S.; Bachert, C.; Hellings, P.W.; Melen, E.; Wickman, M.; Bindslev-Jensen, C.; Eller, E.; O'Hehir, R.E.; Cingi, C.; Gemicioglu, B.; Kalayci, O.; Ivancevich, J.C.; Bousquet, J.; Aberer, W.; Agache, I.; Akdis, C.A.; Akdis, M.; Aliberti, M.R.; Almeida, R.; Amat, F.; Angles, R.; Ansotegui, I.J.; Arnavielle, S.; Asayag, E.; Asarnoj, A.; Arshad, H.; Avolio, F.; Bacci, E.; Baiar-Dini, I.; Barbara, C.; Barbagallo, M.; Baroni, I.; Barreto, B.A.; Basagana, X.; Bateman, E.D.; Bedolla-Barajas, M.; Beghe, B.; Bel, E.H.; Bennoor, K.S.; Benson, M.; Bertorello, L.; Bialoszewski, A.Z.; Bieber, T.; Bjermer, L.; Blain, H.; Blasi, F.; Blua, A.; Marciniak, M.B.; Bogus-Buczynska, I.; Boner, A.L.; Bonini, M.; Bonini, S.; Bosnic-Anticevich, C.S.; Bouchard, J.; Boulet, L.P.; Bourret, R.; Bousquet, P.; Braido, F.; Brightling, C.E.; Brozek, J.; Bucca, C.; Buhl, R.; Buonaiuto, R.; Panaitescu, C.; Cabanas, M.T.B.; Burte, E.; Bush, A.; Caballero-Fonseca, F.; Caillaud, D.; Caimmi, D.; Calderon, M.A.; Camargos, P.A.M.; Camuzat, T.; Canfora, G.; Canonica, G.W.; Carlsen, K.H.; Carreiro-Martins, P.; Carriazo, A.M.; Carr, W.; Cartier, C.; Casale, T.; Castellano, G.; Cepeda, A.M.; Chavannes, N.H.; Chen, Y.; Chiron, R.; Chivato, T.; Chkhartishvili, E.; Chuchalin, A.G.; Chung, K.F.; Ciaravolo, M.M.; Ciceran, A.; Ciprandi, G.; Coehlo, A.C.C.; Colas, L.; Colgan, E.; Coll, J.; Conforti, D.; Sousa, J.C. de; Cortes-Grimaldo, R.M.; Corti, F.; Mc Costa-Dominguez; Courbis al; Cox, L.; Crescenzo, M.; Custovic, A.; Dahlen, S.E.; D'Amato; Dario, C.; Silva, J. da; Dauvilliers, Y.; Darsow, U.; Blay, F. de; Carlo, G. de; Dedeu, T.; Emerson, M.D.F.; Martino, B. de; Rubina, N.P.M.; Deleanu, D.; Demoly, P.; Denburg, J.; Ercolano, S.D.C.; Carluccio, N. di; Didier, A.; Dokic, D.; Dominguez-Silva, M.G.; Douagui, H.; Dray, G.; Dubakiene, R.; Durham, S.R.; Toit, G. du; Dykewicz, M.S.; El-Gamal, Y.; Eklund, P.; Emuzyte, R.; Farrell, J.; Farsi, A.; Mello, J.F. de; Ferrero, J.; Fink-Wagner, A.; Fiocchi, A.; Fok-Kens, W.J.; Forti, S.; Fuentes-Perez, J.M.; Galvez-Romero, J.L.; Gamkrelidze, A.; Garcia-Aymerich, J.; Garcia-Cobas, C.Y.; Garcia-Cruz, M.H.; Genova, S.; Christoff, G.; Gereda, J.E.; Wijk, R.G. van; Gomez, R.M.; Gomez-Vera, J.; Diaz, S.G.; Gotua, M.; Grisle, I.; Guidacci, M.; Guldemond, N.; Gutter, Z.; Guzman, M.; Hajjam, J.; Hernandez, L.; Houri-Hane, J.; Huerta-Villalobos, Y.R.; Humbert, M.; Iaccarino, G.; Ispayeva, Z.; Jares, E.; Jassem, E.; Johnston, S.L.; Joos, G.; Jung, K.S.; Just, J.; Jutel, M.; Kaidashev, I.; Kalyoncu, A.F.; Karjalainen, J.; Kardas, P.; Keith, P.K.; Khaitov, M.; Khaltaev, N.; Kleine-Tebbe, J.; Kowalski, M.L.; Kuitunen, M.; Kull, I.; Kupczyk, M.; Krzych-Falta, E.; Lacwik, P.; Laune
• Date: 2019-04-01
• Journal: Clinical and Experimental Allergy
• Volume: 49
• Issue: 4
• Pages: 442 - 460
• DOI: doi:10.1111/cea.13333