Disruption of PLTP (phospholipid transfer protein)-mediated HDL (high-density lipoprotein) maturation reduces SR-BI (scavenger receptor BI) deficiency-driven atherosclerosis susceptibility despite unexpected metabolic complications

Hoekstra, M.; Sluis, R.J. van der; Hildebrand, R.B.; Lammers, B.; Zhao, Y.; Praticò, D.; ... ; Eck, M. van (2020)

Article / Letter to editor

C]cholesteryl oleate after intravenous VLDL-like particle injection.\nWe have shown that disruption of PLTP-mediated HDL maturation reduces SR-BI deficiency-driven atherosclerosis susceptibility in mice despite the induction of proatherogenic metabolic complications in the double knockout mice.\nOBJECTIVE\nCONCLUSIONS

• Atherosclerosis
• Diet, high fat
• Hypertriglyceridemia
• Mice
• Obesity

• All authors: Hoekstra, M.; Sluis, R.J. van der; Hildebrand, R.B.; Lammers, B.; Zhao, Y.; Praticò, D.; Berkel, T.J.C. van; Rensen, P.C.N.; Kooijman, S.; Jauhiainen, M.; Eck, M. van
• Date: 2020-01-16
• Journal: Arteriosclerosis, Thrombosis, and Vascular Biology
• Volume: 40
• Issue: 3
• Pages: 611 - 623
• DOI: doi:10.1161/ATVBAHA.119.313862