High-dimensional profiling of immunotherapy-responsive immune cells in cancer

Beyrend, G. (2021)

Doctoral Thesis

Immunotherapy approach to cancer is only benefiting to a minority of patients. In this study, we approach cancer solutions by studying the microenvironment and its immunological signature throughout the body by focusing on the systemic immunity with new technology like mass cytometry. By highlighting specific immunological patterns in cancer, we were able to associate responsive immune cells and positive outcome, therefore paving the way to improve immunotherapy in cancer.

• Mass cytometry
• Single-cell analysis
• Single-cell-RNA sequencing
• Bioinformatics
• Immunotherapy
• Cancer

• All authors: Beyrend, G.
• Supervisor: Ossendorp, F.
• Co-supervisor: Arens, R.
• Committee: Borst, J.G.; Haanen, J.B.A.G.; Aerts, J.G.J.V.; Lier, R. van
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2021-06-08
• ISBN (print): 9789493197664
• Sponsorship: Fluidigm