Outcomes of parathyroidectomy versus calcimimetics for secondary hyperparathyroidism and kidney transplantation: a propensity-matched analysis

Koh, E.Y.; Plas, W.Y. van der; Dulfer, R.R.; Pol, R.A.; Kruijf, S.; Rotmans, J.I.; ... ; Dutch Hyperparathyroidism Study Gr (2020)

Article / Letter to editor

Purpose Calcimimetics are currently indicated for severe secondary hyperparathyroidism (SHPT). However, the role of parathyroidectomy (PTX) for these patients is still under debate, and its impact on subsequent kidney transplantation (KTX) is unclear. In this study, we compare the outcomes of kidney transplantation after PTX or medical treatment. Methods Patients who underwent KTX and had SHPT were analyzed retrospectively. Two groups were selected (patients who had either PTX or calcimimetics prior to KTX) using a propensity score for sex, age, donor type, and parathyroid hormone levels (PTH) during dialysis. The primary outcome was graft failure, and secondary outcomes were surgical KTX complications, survival, serum PTH, serum calcium, and serum phosphate levels post-KTX. Results Matching succeeded for 92 patients. After PTX, PTH was significantly lower on the day of KTX as well as at 1 and 3 years post-KTX (14.00 pmol/L (3.80-34.00) vs. 71.30 pmol/L (30.70-108.30),p < 0.01, 10.10 pmol/L (2.00-21.00) vs. 32.35 pmol/L (21.58-51.76),p < 0.01 and 13.00 pmol/L (6.00-16.60) vs. 19.25 pmol/L (13.03-31.88),p = 0.027, respectively). No significant differences in post-KTX calcium and phosphate levels were noted between groups. Severe KTX complications were more common in the calcimimetics group (56.5% vs. 30.4%,p = 0.047). There were no differences in 10-year graft failure and overall survival. Conclusion PTX resulted in lower PTH after KTX in comparison to patients who received calcimimetics. Severe complications were more common after calcimimetics, but graft failure and overall survival were similar.

• Secondary hyperparathyroidism
• Parathyroidectomy
• Calcimimetics
• Kidney transplantation

• All authors: Koh, E.Y.; Plas, W.Y. van der; Dulfer, R.R.; Pol, R.A.; Kruijf, S.; Rotmans, J.I.; Appelman-Dijkstra, N.; Schepers, A.; Borst, M.H. de; Hoorn, E.J.; Ginhoven, T. van; Dijkum, E.J.M.N. van; Vogt, L.; Engelsman, A.F.; Dutch Hyperparathyroidism Study Gr
• Date: 2020-08-11
• Journal: Langenbeck's Archives of Surgery
• Volume: 405
• Issue: 6
• Pages: 851 - 859
• DOI: doi:10.1007/s00423-020-01953-5
• Link: https://link.springer.com/article/10.1007/s00423-020-01953-5