Thrombo-inflammation in cardiovascular disease: an expert consensus document from the third Maastricht consensus conference on thrombosis

d'Alessandro, E.; Becker, C.; Bergmeier, W.; Bode, C.; Bourne, J.H.; Brown, H.; Buller, H.R.; Cate-Hoek, A.J. ten; Cate, V. ten; Cauteren, Y.J.M. van; Cheung, Y.F.H.; Cleuren, A.; Coenen, D.; Crijns, H.J.G.M.; Simone, I. de; Dolleman, S.C.; Klein, C.E.; Fernandez, D.I.; Granneman, L.; Hof, A.T. van t; Henke, P.; Henskens, Y.M.C.; Huang, J.N.; Jennings, L.K.; Jooss, N.; Karel, M.; Kerkhof, D. van den; Klok, F.A.; Kremers, B.; Lammle, B.; Leader, A.; Lundstrom, A.; Mackman, N.; Mannucci, P.M.; Maqsood, Z.; Meijden, P.E.J. van der; Moorsel, M. van; Moran, L.A.; Morser, J.; Mourik, M. van; Navarro, S.; Neagoe, R.A.I.; Olie, R.H.; Paridon, P. van; Posma, J.; Provenzale, I.; Reitsma, P.H.; Scaf, B.; Schurgers, L.; Seelig, J.; Siegbahn, A.; Siegerink, B.; Soehnlein, O.; Soriano, E.M.; Sowa, M.A.; Spronk, H.M.H.; Storey, R.F.; Tantiwong, C.; Veninga, A.; Wang, X.Q.; Watson, S.P.; Weitz, J.; Zeerleder, S.S.; Cate, H. ten; Lina, B.; Christoph, B.; Marc, H.; Peter, K.; GregoryLip, K.R.; Steffen, M.; Philipp, V.; Christian, W.; Johann, W.; Sci Reviewer Comm

doi:doi:10.1055/s-0040-1708035

Persistent URL of this record https://hdl.handle.net/1887/3184750

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Medicine / Leiden University Medical Centre (LUMC)

d'Alessandro, E.; Becker, C.; Bergmeier, W.; Bode, C.; Bourne, J.H.; Brown, H.; ... ; Sci Reviewer Comm (2020)

Thrombo-inflammation in cardiovascular disease: an expert consensus document from the third Maastricht consensus conference on thrombosis

Article / Letter to editor

Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6...Show moreThrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.Show less

myocardial infarction

stroke

platelets