Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/3184536

In Collections

This item can be found in the following collections:

Bisson, J.I.; Deursen, R. van; Hannigan, B.; Kitchiner, N.; Barawi, K.; Jones, K.; ... ; Vermetten, E. (2020)

Randomized controlled trial of multi-modular motion-assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment-resistant post-traumatic stress disorder

Article / Letter to editor
Objective To explore the potential efficacy of multi-modular motion-assisted memory desensitization and reprocessing (3MDR) in British military veterans with treatment-resistant service-related PTSD. Methods Exploratory single-blind, randomized, parallel arm, cross-over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome. Results A total of 42 participants (all male) were randomized with 83% retention at 12 weeks and 86% at 26 weeks. The difference in mean Clinician-Administered PTSD Scale for DSM-5 scores between the immediate and delayed 3MDR arms was -9.38 (95% CI -17.33 to -1.44,P = 0.021) at 12 weeks and -3.59 (-14.39 to 7.20,P = 0.513) at 26 weeks when both groups had received 3MDR. The likely effect size of 3MDR was found to be 0.65. Improvements were maintained at 26-week follow-up. 3MDR was found to be acceptable to most, but not all, participants. Several factors that may impact efficacy and acceptability of 3MDR...Show moreObjective To explore the potential efficacy of multi-modular motion-assisted memory desensitization and reprocessing (3MDR) in British military veterans with treatment-resistant service-related PTSD. Methods Exploratory single-blind, randomized, parallel arm, cross-over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome. Results A total of 42 participants (all male) were randomized with 83% retention at 12 weeks and 86% at 26 weeks. The difference in mean Clinician-Administered PTSD Scale for DSM-5 scores between the immediate and delayed 3MDR arms was -9.38 (95% CI -17.33 to -1.44,P = 0.021) at 12 weeks and -3.59 (-14.39 to 7.20,P = 0.513) at 26 weeks when both groups had received 3MDR. The likely effect size of 3MDR was found to be 0.65. Improvements were maintained at 26-week follow-up. 3MDR was found to be acceptable to most, but not all, participants. Several factors that may impact efficacy and acceptability of 3MDR were identified. Conclusion 3MDR is a promising new intervention for treatment-resistant PTSD with emerging evidence of effect.Show less
PTSD
treatment
RCT
3MDR
military veterans
All authors
Bisson, J.I.; Deursen, R. van; Hannigan, B.; Kitchiner, N.; Barawi, K.; Jones, K.; Pickles, T.; Skipper, J.; Young, C.; Abbott, L.R.; Gelderen, M. van; Nijdam, M.J.; Vermetten, E.
Date
2020-06-28
Journal
Acta Psychiatrica Scandinavica
Volume
142
Issue
2
Pages
141 - 151
DOI
doi:10.1111/acps.13200
Link
https://onlinelibrary.wiley.com/doi/10.1111/acps.13200