Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb)

Katagiri, Y.; Torii, R.; Takahashi, K.; Tenekecioglu, E.; Asano, T.; Chichareon, P.; ... ; Onuma, Y. (2020)

Article / Letter to editor

Aims: The aim of this study was to assess the acute performance of the 95 mu m ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries.Methods and results: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two aims. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21 +/- 1.97 vs 2.25 +/- 1.71 Pa, p=0.314).Conclusions: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 mu m were comparable to those in the XIENCE metallic DES.

• bioresorbable scaffolds
• drug-eluting stent
• optical coherence tomography
• QCA

• All authors: Katagiri, Y.; Torii, R.; Takahashi, K.; Tenekecioglu, E.; Asano, T.; Chichareon, P.; Tomaniak, M.; Piek, J.J.; Wykrzykowska, J.J.; Bullett, N.; Ahmed, N.; Al-Lamee, K.; Al-Lamee, R.; Leclerc, G.; Kitslaar, P.; Dijkstra, J.; Reiber, J.H.C.; Poon, E.K.W.; Bourantas, C.V.; Gijsen, F.; Serruys, P.W.; Onuma, Y.
• Date: 2020-06-01
• Journal: Eurointervention
• Volume: 16
• Issue: 2
• Pages: E141 - E146
• DOI: doi:10.4244/EIJ-D-18-01190
• Link: https://eurointervention.pcronline.com/article/preclinical-evaluation-of...