Development and external validation of nomograms to predict sarcoma-specific death and disease progression after surgical resection of localized high-grade conventiona primary central chondrosarcoma and dedifferentiated chondrosarcoma A RETROSPECTIVE, MULTICENTRE COHORT STUDY

Tsuda, Y.; Tsoi, K.; Stevenson, J.D.; Laitinen, M.; Ferguson, P.C.; Wunder, J.S.; Griffin, A.M.; Sande, M.A.J. van de; Praag, V. van; Leithner, A.; Fujiwara, T.; Yasunaga, H.; Matsui, H.; Parry, M.C.; Jeys, L.M.

doi:doi:10.1302/0301-620X.102B12.BJJ-2020-0810.R1

AimsOur aim was to develop and validate nomograms that would predict the cumulative incidence of sarcoma-specific death (CISSD) and disease progression (CIDP) in patients with localized high-grade primary central and dedifferentiated chondrosarcoma.MethodsThe study population consisted of 391 patients from two international sarcoma centres (development cohort) who had undergone definitive surgery for a localized high-grade (histological grade II or III) conventional primary central chondrosarcoma or dedifferentiated chondrosarcoma. Disease progression captured the first event of either metastasis or local recurrence. An independent cohort of 221 patients from three additional hospitals was used for external validation. Two nomograms were internally and externally validated for discrimination (c-index) and calibration plot.ResultsIn the development cohort, the CISSD at ten years was 32.9% (95% confidence interval (CI) 19.8% to 38.4%). Age at diagnosis, grade, and surgical margin were...Show moreAimsOur aim was to develop and validate nomograms that would predict the cumulative incidence of sarcoma-specific death (CISSD) and disease progression (CIDP) in patients with localized high-grade primary central and dedifferentiated chondrosarcoma.MethodsThe study population consisted of 391 patients from two international sarcoma centres (development cohort) who had undergone definitive surgery for a localized high-grade (histological grade II or III) conventional primary central chondrosarcoma or dedifferentiated chondrosarcoma. Disease progression captured the first event of either metastasis or local recurrence. An independent cohort of 221 patients from three additional hospitals was used for external validation. Two nomograms were internally and externally validated for discrimination (c-index) and calibration plot.ResultsIn the development cohort, the CISSD at ten years was 32.9% (95% confidence interval (CI) 19.8% to 38.4%). Age at diagnosis, grade, and surgical margin were found to have significant effects on CISSD and CIDP in multivariate analyses. Maximum tumour diameter was also significantly associated with CISSD. In the development cohort, the c-indices for CISSD and CIDP at five years were 0.743 (95% CI 0.700 to 0.819) and 0.761 (95% CI 0.713 to 0.800), respectively. When applied to the validation cohort, the c-indices for CISSD and CIDP at five years were 0.839 (95% CI 0.763 to 0.916) and 0.749 (95% CI 0.672 to 0.825), respectively. The calibration plots for these two nomograms demonstrated good fit.ConclusionOur nomograms performed well on internal and external validation and can be used to predict CISSD and CIDP after resection of localized high-grade conventional primary central and dedifferentiated chondrosarcomas. They provide a new tool with which clinicians can assess and advise individual patients about their prognosis.Show less

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Development and external validation of nomograms to predict sarcoma-specific death and disease progression after surgical resection of localized high-grade conventiona primary central chondrosarcoma and dedifferentiated chondrosarcoma A RETROSPECTIVE, MULTICENTRE COHORT STUDY