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Saadah, N.H.; Schipperus, M.R.; Wiersum-Osselton, J.C.; Kraaij, M.G. van; Caram-Deelder, C.; Beckers, E.A.M.; ... ; Bom, J.G. van der (2020)

Transition from fresh frozen plasma to solvent/detergent plasma in the Netherlands: comparing clinical use and transfusion reaction risks

Article / Letter to editor
Plasma transfusion is indicated for replenishment of coagulative pro- teins to stop or prevent bleeding. In 2014, the Netherlands switched from using similar to 300mL fresh frozen plasma (FFP) units to using 200mL Omniplasma, a solvent/detergent treated pooled plasma (SD plasma), units. We evaluated the effect of the introduction of SD plasma on clinical plasma use, associated bleeding, and transfusion reaction incidences. Using diagnostic data from six Dutch hospitals, national blood bank data, and national hemovigilance data for 2011 to 2017, we compared the plasma/red blood cell (RBC) units ratio (f) and the mean number of plasma and RBC units transfused for FFP (similar to 300mL) and SD plasma (200mL) for various patient groups, and calculated odds ratios comparing their associated transfusion reaction risks. Analyzing 13,910 transfusion episodes, the difference (Delta f = f(SD) (-) f(FFP)) in mean plasma/RBC ratio (f) was negligible (Delta f(entire-cohort) = 0.01 [95%...Show morePlasma transfusion is indicated for replenishment of coagulative pro- teins to stop or prevent bleeding. In 2014, the Netherlands switched from using similar to 300mL fresh frozen plasma (FFP) units to using 200mL Omniplasma, a solvent/detergent treated pooled plasma (SD plasma), units. We evaluated the effect of the introduction of SD plasma on clinical plasma use, associated bleeding, and transfusion reaction incidences. Using diagnostic data from six Dutch hospitals, national blood bank data, and national hemovigilance data for 2011 to 2017, we compared the plasma/red blood cell (RBC) units ratio (f) and the mean number of plasma and RBC units transfused for FFP (similar to 300mL) and SD plasma (200mL) for various patient groups, and calculated odds ratios comparing their associated transfusion reaction risks. Analyzing 13,910 transfusion episodes, the difference (Delta f = f(SD) (-) f(FFP)) in mean plasma/RBC ratio (f) was negligible (Delta f(entire-cohort) = 0.01 [95% confidence interval (CI): -0.02 - 0.05]; P=0.48). SD plasma was associated with fewer RBC units transfused per episode in gynecological (difference of mean number of units -1.66 [95% CI: -2.72, -0.61]) and aneurysm (-0.97 [-1.59, -0.35]) patients. SD plasma was further associated with fewer anaphylactic reactions than FFP (odds ratio 0.37 [0.18, 0.77; P<0.01]) while the differences for most transfusion reactions were not statistically significant. SD plasma units, despite being one third smaller in volume than FFP units, are not associated with a higher plasma/RBC ratio. SD plasma is associated with fewer anaphylactic reactions than FFP plasma/RBC units ratio.Show less
All authors
Saadah, N.H.; Schipperus, M.R.; Wiersum-Osselton, J.C.; Kraaij, M.G. van; Caram-Deelder, C.; Beckers, E.A.M.; Leyte, A.; Rondeel, J.M.M.; Vooght, K.M.K. de; Weerkamp, F.; Zwaginga, J.J.; Bom, J.G. van der
Date
2020-04-01
Journal
Haematologica
Volume
105
Issue
4
Pages
1158 - 1165
DOI
doi:10.3324/haematol.2019.222083
Link
https://haematologica.org/article/view/9350