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Linssen, P.B.C.; Brunner-La Rocca, H.P.; Schalkwijk, C.G.; Beulens, J.W.J.; Elders, P.J.M.; Heijden, A.A. van der; ... ; Henry, R.M.A. (2020)

Serum matrix metalloproteinases and left atrial remodeling-the Hoorn study

Article / Letter to editor
Extracellular matrix protein turnover may play an important role in left atrial (LA) remodelling. The aim is to investigate the associations between matrix metalloproteinase (MMPs), tissue inhibitor of metalloproteinase (TIMP-1) and LA volume index (LAVI) and if these associations are independent of TIMP-1 levels. Participants from The Hoorn Study, a population-based cohort study (n= 674), underwent echocardiography. Serum MMPs (i.e., MMP-1, MMP-2, MMP-3, MMP-9, and MMP-10) and TIMP-1 levels were measured with ELISA. Multiple linear regression analyses were used. MMP-1 levels were not associated with LAVI. Higher MMP-2 levels were associated with larger LAVI (regression coefficient per SD increase in MMP (95% CI); 0.03 (0.01; 0.05). Higher MMP-3 and MMP-9 levels were associated with smaller LAVI; -0.04 (-0.07; -0.01) and -0.04 (-0.06; -0.02) respectively. Only in women were higher MMP-10 levels associated with larger LAVI; 0.04 (0.00; 0.07,p-interaction 0.04). Additionally, only in...Show moreExtracellular matrix protein turnover may play an important role in left atrial (LA) remodelling. The aim is to investigate the associations between matrix metalloproteinase (MMPs), tissue inhibitor of metalloproteinase (TIMP-1) and LA volume index (LAVI) and if these associations are independent of TIMP-1 levels. Participants from The Hoorn Study, a population-based cohort study (n= 674), underwent echocardiography. Serum MMPs (i.e., MMP-1, MMP-2, MMP-3, MMP-9, and MMP-10) and TIMP-1 levels were measured with ELISA. Multiple linear regression analyses were used. MMP-1 levels were not associated with LAVI. Higher MMP-2 levels were associated with larger LAVI (regression coefficient per SD increase in MMP (95% CI); 0.03 (0.01; 0.05). Higher MMP-3 and MMP-9 levels were associated with smaller LAVI; -0.04 (-0.07; -0.01) and -0.04 (-0.06; -0.02) respectively. Only in women were higher MMP-10 levels associated with larger LAVI; 0.04 (0.00; 0.07,p-interaction 0.04). Additionally, only in women were higher TIMP-1 levels associated with smaller LAVI; -0.05 (-0.09; -0.01,p-interaction 0.03). The associations between MMPs and LAVI were independent of TIMP-1 levels. In conclusion, serum MMPs are associated with LAVI, independent of CVD risk factors and TIMP-1 levels. In addition, these associations differ according to sex and within MMP subgroups. This shows that the role of MMPs in LA remodelling is complex.Show less
matrix metalloproteinase (MMPs)
tissue inhibitor of matrix metalloproteinases (TIMP-1)
LA-volume index
diastolic dysfunction
echocardiography
All authors
Linssen, P.B.C.; Brunner-La Rocca, H.P.; Schalkwijk, C.G.; Beulens, J.W.J.; Elders, P.J.M.; Heijden, A.A. van der; Slieker, R.C.; Stehouwer, C.D.A.; Henry, R.M.A.
Date
2020-07-01
Journal
International Journal of Molecular Sciences
Volume
21
Issue
14
DOI
doi:10.3390/ijms21144944
Link
https://www.mdpi.com/1422-0067/21/14/4944