A proposal for the interpretation of serum IGF-I concentration as part of laboratory screening in children with growth failure

Wit, J.M.; Bidlingmaier, M.; Bruin, C. de; Oostdijk, W. (2020)

Article / Letter to editor

The serum insulin-like growth factor-I (IGF-I) concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue that the cut-off limit is dependent on the clinical pre-test likelihood of GHD and propose a diagnostic strategy in which the cut-off limit varies between zero to -2 SDS.

• Short stature
• growth disorders
• IGF-I
• IGFBP-3

• All authors: Wit, J.M.; Bidlingmaier, M.; Bruin, C. de; Oostdijk, W.
• Date: 2020-06-01
• Journal: Journal of Clinical Research in Pediatric Endocrinology
• Volume: 12
• Issue: 2
• Pages: 130 - 139
• DOI: doi:10.4274/jcrpe.galenos.2019.2019.0176
• Link: https://cms.galenos.com.tr/Uploads/Article_32184/JCRPE-12-130-En.pdf