Leiden University Scholarly Publications

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Nabuurs, C.H.; Kievit, W.; BSc, N.L.; Leemans, C.R.; Smit, C.F.G.M.; Brekel, M.W.M. van den; ... ; Kunst, H.P.M. (2020)

Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal

Article / Letter to editor
Background Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC...Show moreBackground Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.Show less
disease-free survival
neoplasm staging
prognosis
squamous cell carcinoma
temporal bone
All authors
Nabuurs, C.H.; Kievit, W.; BSc, N.L.; Leemans, C.R.; Smit, C.F.G.M.; Brekel, M.W.M. van den; Pauw, R.J.; Laan, B.F.A.M. van der; Jansen, J.C.; Lacko, M.; Braunius, W.W.; Morita, S.; Wierzbicka, M.; Matoba, T.; Hanai, N.; Takes, R.P.; Kunst, H.P.M.
Date
2020-08-13
Journal
Head and Neck
Volume
42
Issue
12
Pages
3609 - 3622
DOI
doi:10.1002/hed.26424
Link
https://onlinelibrary.wiley.com/doi/10.1002/hed.26424