Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Uden, T.; Bertaina, A.; Abrahamsson, J.; Ansari, M.; Balduzzi, A.; Bourquin, J.; ... ; Sauer, M.G. (2020)

Article / Letter to editor

Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0 center dot 0001). Achievement of a subsequent remission impacted survival (P = <0 center dot 0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0 center dot 046) and donor choice (matched family vs. matched unrelated donor, P = 0 center dot 029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%.

• allogeneic hematopoietic stem cell transplantation
• children
• relapse
• acute myeloid leukemia
• second hematopoietic stem cell transplantation

• All authors: Uden, T.; Bertaina, A.; Abrahamsson, J.; Ansari, M.; Balduzzi, A.; Bourquin, J.; Gerhardt, C.; Bierings, M.; Hasle, H.; Lankester, A.; Mischke, K.; Moore, A.S.; Nivison-Smith, I.; Pieczonka, A.; Peters, C.; Sedlacek, P.; Reinhardt, D.; Stein, J.; Versluys, B.; Wachowiak, J.; Willems, L.; Zimmermann, M.; Locatelli, F.; Sauer, M.G.
• Date: 2020-02-03
• Journal: British Journal of Haematology
• DOI: doi:10.1111/bjh.16441