The role of autophagy during carbon starvation in Aspergillus niger

Burggraaf, M.A. (2021)

Doctoral Thesis

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell. The process is highly induced by carbon starvation conditions. In this thesis, different roles of autophagy in the filamentous fungus Aspergillus niger were studied, focusing on its role during carbon starvation, endoplasmic reticulum (ER) stress and unconventional protein secretion.

• Aspergillus niger
• Autophagy
• Carbon starvation
• Transcriptome
• ER-associated degradation (ERAD)
• Unconventional protein secretion (UPS)

• All authors: Burggraaf, M.A.
• Supervisor: Ram, A.F.J.; Punt, P.J.; Hondel, C.A.M.J.J. van den
• Committee: Wezel, G.P. van; Winde, J.H. de; Kleij, I.J. van der; Meijer, A.H.; Pócsi, I.; Wösten, H.A.B.
• Qualification: Doctor (dr.)
• Awarding Institution: Institute of Biology Leiden (IBL), Faculty of Science, Leiden University
• Date: 2021-05-25
• ISBN (print): 9789464232394