Prognostic and predictive biomarkers in colorectal cancer. Towards precision medicine

Reimers, M.S. (2015)

Doctoral Thesis

The aim of this thesis was to define prognostic and predictive biomarkers in colorectal cancer for improved risk stratification and treatment benefit in the individual patient, with the introduction of precision medicine in the near future as the ultimate goal. By __definition, precision medicine is a multi-faceted approach to medicine that integrates molecular and clinical research with patient data and clinical outcome, and places the patient at the center of all elements. This thesis is divided in three parts. In Part one prognostic biomarkers in CRC are investigated, in Part two aspirin treatment and related predictive biomarkers for aspirin treatment benefit in colon cancer are investigated and finally, in Part three, the use of predictive and prognostic biomarkers in clinical practice, its utility and the road to precision medicine are discussed.

• Aspirin treatment
• Biomarkers
• Prognosis
• Colorectal cancer
• Colorectal cancer, prognosis, biomarkers, aspirin treatment

• All authors: Reimers, M.S.
• Supervisor: Velde, C.J.H. van de
• Co-supervisor: Kuppen, P.J.K.; Liefers, G.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2015-01-08
• ISBN (print): 9789461695918
• Sponsorship: Unrestricted grant from the Sloos-Alandt family