Pathophysiology of the GH/IGF-1 axis : long-term consequences on joints and bone

Claessen, K.M.J.A. (2014)

Doctoral Thesis

In this thesis, a number of observations are described in acromegaly patients with cured or biochemically well-controlled disease during long-term follow-up. These observations focus on the long-term consequences of the disease on joints and bone. In addition, we investigated the role of the Growth Hormone (GH)/Insulin-like Growth Factor-1 (IGF-1) axis, including the possible effects of the exon 3 deleted GH receptor (d3-GHR) polymorphism, in patients with primary osteoarthritis (OA) that have serum IGF-1 levels within the normal range. Finally, we studied the long-term consequences of recombinant human GH (rhGH) replacement in GH Deficient (GHD) adults, focusing on the cardiovascular effects and the effects on bone in comparison to healthy controls.

• Metabolic syndrome
• GHD
• Vertebral fractures
• IGF-1
• GH
• Joints
• Bone
• Acromegaly

• All authors: Claessen, K.M.J.A.
• Supervisor: Pereira, A.M.; Kloppenburg, M.
• Co-supervisor: Biermasz, N.R.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2014-12-17
• ISBN (print): 9789461087980
• Sponsorship: Ferring BV, Pfizer BV, Novartis Pharma BV, Novo Nordisk BV, Ipsen Farmaceutica BV, Sanofi-Aventis BV, ABN AMRO