Narcolepsy beyond sleepiness : endocrine, metabolic and other aspects

Donjacour, C.E.H.M. (2014)

Doctoral Thesis

The thesis contains a large study in which eight male hypocretin deficient narcolepsy with cataplexy patients and eight matched controls were enrolled. Blood was sampled before and on the 5th day of SXB administration. SXB was taken 2 times 3g per night for 5 consecutive nights. Both groups underwent 24-h blood sampling and many hormones (prolactin, Growth hormone, melatonin, ghrelin, leptin) were measured and compared before and during SXB treatment. A study using the golden standard on insuline sensitivity is decribed to compare insuline sensitivity between patients and controls, and between patients, before and during satisfactory SXB treatment. ANother study describes body and skintemperature differences between narcolepsy patients and controls. Another chapter describes a rarely described, common feature in narcolepsy, in which patients mistake the memory of a dream for a real experience. In another chapter describes that date of birth is not a risk factor for narcolepsy.

• Melatonin
• Ghrelin
• Delusion
• Growth hormone
• Prolactin
• Insulin
• Hypocretin
• Metabolism
• Narcolepsy

• All authors: Donjacour, C.E.H.M.
• Supervisor: Pijl, H.
• Co-supervisor: Lammers, G.J.; Overeem, S.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2014-12-18
• ISBN (print): 9789090283876
• Sponsorship: SEIN, UCB Pharma, Koninklijke Auping, Wave Medical, Nederlandse vereniging voor Narcolepsie, Nederlandse vereniging voor slaap- en waak onderzoek, Heinen en Löwenstein, Chipsoft