Function and behavior of CD8+ T cells in the skin

Ariotti, S. (2014)

Doctoral Thesis

The subject of this thesis is the study of the function and behavior of CD8+ T cells that have exited the circulation and entered a tissue in order to get rid of an infection. In particular, the research focus on 1- how effector CD8+ T cells can localize infected cells within a tissue. 2-how, once the infection has been cleared, effector CD8+ T cells become memory T cells that take up permanent residence in the tissue; also, how the patrolling behavior that these cells acquire in the tissue allows quick control of local secondary infections. 3-how tissue-resident memory CD8+ T cells that have re-encountered a specific antigen can induce an increased level of local immune protection against infections.

• Intravital imaging
• Vaccination
• Viral immunity
• T cell memory

• All authors: Ariotti, S.
• Supervisor: Schumacher, T.N.M.; Haanen, J.B.A.G.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2014-10-02