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Amersfoort, J.; Kuiper, J. (2017)

T cell metabolism in metabolic disease-associated autoimmunity

Article / Letter to editor
This review discusses the relevant metabolic pathways and their regulators which show potential for T cell metabolism-based immunotherapy in diseases hallmarked by both metabolic disease and autoimmunity. Multiple therapeutic approaches using existing pharmaceuticals are possible from a rationale in which T cell metabolism forms the hub in dampening the T cell component of autoimmunity in metabolic diseases. Future research into the effects of a metabolically aberrant micro-environment on T cell metabolism and its potential as a therapeutic target for immunomodulation could lead to novel treatment strategies for metabolic disease-associated autoimmunity.
T cells
Cellular metabolism
Autophagy
Diabetes
Dyslipidemia
Therapeutics
All authors
Amersfoort, J.; Kuiper, J.
Date
2017
Journal
Immunobiology
Volume
222
Issue
10
Pages
925 - 936