Natural and non-natural factors influencing Alzheimer´s Aβ

Luo, J. (2014)

Doctoral Thesis

Alzheimer's disease is manifested in amyloid fibril but caused by protofibril oligomers of A_ peptide and tau protein. I discovered a molecular mechanism which involves a new globular state of the A_ peptide formed by protofibril oligomers, and from which fibrils can nucleate. Another striking finding in my thesis is to present new concept to inhibit amyloid fibrillation. For instance, natural factors found in vivo, such as ,lysozyme, insulin and spermine, and non-natural factors found in vitro, like gramicidin S, can interfere with the toxicity and fibrillation of A_.

• Gramicidin S
• Alzheimer
• Fibrillation
• Polyamines
• Non-chaperone protein
• Aggregates
• Fibril
• A_

• All authors: Luo, J.
• Supervisor: Abrahams, J.P.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Science, Leiden University
• Date: 2014-06-18
• ISBN (print): 9789461087041