Perspectives in the treatment of cardiovascular disease : from prognostic parameters to therapeutic modalities

Dharma, S. (2013)

Doctoral Thesis

Over the last decade, a tremendous progress has been made in cardiovascular medicine. The progress includes the treatment of coronary artery disease (CAD) and peripheral artery disease. In CAD, several advances have been made in the management of patients with acute myocardial infarction (AMI) such as: 1) the importance of networking in the treatment of AMI; 2) perspectives on how to improve the results of primary percutaneous coronary intervention (PCI) procedures including: (i) the administration of a glycoprotein IIb/ IIIa inhibitor (GPI); (ii) strategies for __fighting__ the coronary thrombus during primary PCI; (iii) choice of vascular access site (radial versus femoral artery approach) for primary PCI; (iv) choice of stents (drug eluting versus bare metal stent) for patients with acute ST-segment elevation myocardial infarction (STEMI); and 3) the use of intra-aortic balloon pump (IABP) in acute coronary syndrome (ACS) patients. Another important perspective related to patients with AMI is the utilization of simple, inexpensive but accurate biomarkers with prognostic value such as plasma uric acid concentration and leukocyte count, which are particularly useful in a rural area when other established markers are not available.

• Spasmolytic cocktail
• System of care
• Primary PCI
• Pre-hospital setting
• In-hospital setting
• Biomarkers
• AMI
• Acute MI
• Access site

• All authors: Dharma, S.
• Supervisor: Jukema, J.W.; Laarse, A. van der
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2013-08-29
• ISBN (print): 9786021791332