Improving breast cancer outcome by preoperative systemic therapy and image-guided surgery

Mieog, J.S.D. (2011)

Doctoral Thesis

This thesis consists of two parts. In part I, we have demonstrated that preoperatively administrated systemic (neoadjuvant) therapy is a feasible treatment strategy in early stage breast cancer to achieve improved surgical options and to assess tumor response. We also demonstrated that overexpression of the breast cancer stem cell marker aldehyde dehydrogenase-1 in early stage breast cancer patients is inversely associated with age and is of prognostic importance. In part II, we have demonstrated proof-of-principle of intraoperative tumor detection and image-guided tumor resection by using the novel technique of near-infrared fluorescence imaging. We have performed two clinical trials to optimize the use of indocyanine green as a near-infrared fluorescence lymphatic tracer for the sentinel lymph node procedure in breast cancer patients.

• Image-guided surgery
• Fluorescence
• Breast cancer stem cell
• Surgery
• Preoperative therapy
• Breast cancer

• All authors: Mieog, J.S.D.
• Supervisor: Velde, C.J.H. van de
• Co-supervisor: Vahrmeijer, A.L.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2011-10-26
• ISBN (print): 9789461691507
• Sponsorship: KWF CTMM ZonMw Sacha Swarttouw-Hijmans Foundation