Leiden University Scholarly Publications

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Kuiper, P. (2011)

GEP-NET : rare tumour connections. Pathophysiological aspects of gastroenteropancreatic neuroendocrine tumours

Doctoral Thesis
Clinical behaviour of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) varies strikingly, both in terms of symptoms and outcome. An understanding of the basic biology unique to GEP-NETs is necessary for optimum management of patients with these complex tumors. Although markers for GEP-NETs exist, sensitive and specific markers that predict tumor growth and behaviour are lacking. The general purpose of the studies described in this thesis was to investigate the epidemiology, diagnosis and pathogenesis of GEP-NETs in The Netherlands, to reveal insights in the pathological mechanisms contributing to the development and progression of these tumors. Not only worldwide but also in The Netherlands, the incidence of these tumors is increasing. The diverse studies contribute to a better understanding of the role of angiogenesis, neuropeptides and matrix metallo-proteinases in neuroendocrine tumors of the digestive tract and pancreas. Additional studies and further research will...Show moreClinical behaviour of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) varies strikingly, both in terms of symptoms and outcome. An understanding of the basic biology unique to GEP-NETs is necessary for optimum management of patients with these complex tumors. Although markers for GEP-NETs exist, sensitive and specific markers that predict tumor growth and behaviour are lacking. The general purpose of the studies described in this thesis was to investigate the epidemiology, diagnosis and pathogenesis of GEP-NETs in The Netherlands, to reveal insights in the pathological mechanisms contributing to the development and progression of these tumors. Not only worldwide but also in The Netherlands, the incidence of these tumors is increasing. The diverse studies contribute to a better understanding of the role of angiogenesis, neuropeptides and matrix metallo-proteinases in neuroendocrine tumors of the digestive tract and pancreas. Additional studies and further research will possible lead to new diagnostic and therapeutic implications of endoglin, bombesin and MMPs in patients with gastroenteropancreatic neuroendocrine tumors.Show less
Gastroenteropancreatic neuroendocrine tumours
Pancreas
Endoglin
Matrilysin
Insulin-like growth factor
Gastrinomas
Zollinger-Ellison syndrome
All authors
Kuiper, P.
Supervisor
Lamers, C.B.H.W.
Co-supervisor
Verspaget, H.W.; Biemond, I.
Qualification
Doctor (dr.)
Awarding Institution
Leiden University Medical Center (LUMC), Leiden University
Date
2011-04-21
ISBN (print)
9789090260433

Funding

Sponsorship
Nederlandse Verening van Gastroenterologie Nederlandse Verening van Gastroenterologie Sectie Experimentele Gastroenterologie AstraZeneca B.V. Falk Pharma Benelux B.V. Ipsen Farmaceutica B.V. Novartis Oncology Stichting voor Patienten met Kanker aan het Spijsverteringskanaal (SPKS)