Leiden University Scholarly Publications

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Roes, S.D. (2010)

Magnetic resonance imaging techniques for risk stratification in cardiovascular disease

Doctoral Thesis
Cardiovascular disease is an important problem in the western world and identification of individuals at risk of cardiovascular disease and identification of patients with cardiovascular disease who are at risk of complications is important in order to reduce morbidity and mortality. This thesis shows the potential of MRI for risk stratification in cardiovascular disease. MRI enables assessment of morphology and function of the aortic vessel wall, which is important since the thickness and stiffness of the aortic vessel wall are related with coronary artery disease and cardiovascular events. Furthermore, the potential of MRI for visualization of the coronary arteries and assessment of coronary artery flow is explored. Although, this technique is not yet routinely used, ongoing research may in the future make MRI a valuable technique for detection of coronary artery disease. In addition, it is demonstrated that MRI is an excellent technique for detection and quantification of valve...Show moreCardiovascular disease is an important problem in the western world and identification of individuals at risk of cardiovascular disease and identification of patients with cardiovascular disease who are at risk of complications is important in order to reduce morbidity and mortality. This thesis shows the potential of MRI for risk stratification in cardiovascular disease. MRI enables assessment of morphology and function of the aortic vessel wall, which is important since the thickness and stiffness of the aortic vessel wall are related with coronary artery disease and cardiovascular events. Furthermore, the potential of MRI for visualization of the coronary arteries and assessment of coronary artery flow is explored. Although, this technique is not yet routinely used, ongoing research may in the future make MRI a valuable technique for detection of coronary artery disease. In addition, it is demonstrated that MRI is an excellent technique for detection and quantification of valve regurgitation. MRI also allows for quantification of scar tissue and contractile reserve in patients with ischemic cardiomyopathy enabling assessment of viability, which is important for optimization of treatment and prognosis. Finally, it is demonstrated that infarct size and infarct tissue heterogeneity measured with MRI are important predictors for long-term survival.Show less
Magnetic resonance imaging
Cardiovascular disease
Risk stratification
All authors
Roes, S.D.
Supervisor
Roos, A. de; Bax J.J.
Co-supervisor
Westenberg, J.J.M.
Qualification
Doctor (dr.)
Awarding Institution
Leiden University Medical Center (LUMC), Leiden University
Date
2010-06-24
ISBN (print)
9789090254173

Funding

Sponsorship
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged. Additional financial support is provided by Foundation Imago, Oegstgeest; Division of Image Processing (LKEB), Department of Radiology, LUMC; Philips Healthcare; Servier Nederland Farma B.V.; Guerbet Nederland B.V.; Solvay Pharmaceuticals B.V.; Toshiba Medical Systems Nederland; Bayer Schering Pharma; and Eli Lilly Nederland B.V.