Betapapillomavirus infections : natural history and disease association

Koning, M.N.C. de (2009)

Doctoral Thesis

This thesis starts with a general introduction and a description of the development of a detection and genotyping method for Betapapillomavirus types. This genotyping method is used in three chapters to acquire more knowledge on the natural history of Betapapillomavirus infection. Very little is known about this subject and more knowledge could support future studies into the clinical relevance of these viruses. Furthermore, three subsequent chapters focus on possible associations of betaPV infection with three different (pre)malignant diseases. A final chapter includes general discussion and conclusions.

• Betapapillomavirus
• Genotyping
• Non-melanoma skin cancer
• Papillomavirus
• PCR
• Reverse hybridisation

• All authors: Koning, M.N.C. de
• Supervisor: Spaan, W.J.M.
• Co-supervisor: Quint, W.G.V.; Feltkamp, M.C.W.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2009-11-05
• Sponsorship: Research described in this thesis was supported by DDL Diagnostic Laboratory, by the Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, by EC grant QLK-CT-00201179, by Labo Bio-medical Products B.V., and by Stichting Pathologie Onderzoek en Ontwikkeling. Publication of this thesis has been supported by the Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center.