Magnetic resonance imaging of atherosclerosis : studies in visceral obesity

Alizadeh Dehnavi, R. (2009)

Doctoral Thesis

The aim of this thesis was to explore the relation between visceral obesity and the accompanying metabolic disturbances, systemic inflammation and the atherosclerotic process. A newly developed magnetic resonance vessel wall imaging technique was implemented in phenotyping patients and as a therapeutic endpoint in a randomised controlled setting. A three step approach was chosen for this purpose. First, the magnetic resonance black blood vessel wall imaging technique at the magnetic field strength of 3 Tesla was developed and validated. Secondly, phenotyping of viscerally obese subjects was performed with special attention for the role of systemic inflammation and atherosclerosis. Finally, in the setting of a randomised controlled trial, the impact of reducing visceral obesity and systemic inflammation with lifestyle intervention and rosiglitazone treatment (PPARg agonist) on the progression of atherosclerosis was assessed.

• Atherosclerosis
• MRI
• Inflammation
• CRP
• Visceral obesity
• Rosiglitazone

• All authors: Alizadeh Dehnavi, R.
• Supervisor: Romijn, J.A.; Roos, A. de; Jukema, J.W.
• Qualification: Doctor (dr.)
• Awarding Institution: faculty of Social and Behavioural Science, Leiden University
• Date: 2009-10-06
• ISBN (print): 9789085595663