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Strategies in prevention and treatment of prosthetic joint infections
Antibiotics are prophylactically administered to arthroplasty patients, but to date it remained unclear how many doses of prophylaxis provided the best protection. 90% of hospitals provide multiple doses, while 10% of hospitals administer a single dose prophylaxis.
Our study shows that, with 242.179 included patients from the LROI database, there seems to be no difference in the risk of complete revision for infection between single dose and multiple dose prophylaxis.
We have also evaluated several treatment options for two-stage revision of infected hip and knee prostheses.
The use of a functional articulating antibiotic loaded spacer leads to a comparable infection eradication rate, improved patient reported outcome and less complications compared to a prefabricated standard spacer...Show moreWe studied the prevention and treatment of prosthetic joint infections. This topic is of interest because the number of annually performed arthroplasty procedures is rising worldwide.
Antibiotics are prophylactically administered to arthroplasty patients, but to date it remained unclear how many doses of prophylaxis provided the best protection. 90% of hospitals provide multiple doses, while 10% of hospitals administer a single dose prophylaxis.
Our study shows that, with 242.179 included patients from the LROI database, there seems to be no difference in the risk of complete revision for infection between single dose and multiple dose prophylaxis.
We have also evaluated several treatment options for two-stage revision of infected hip and knee prostheses.
The use of a functional articulating antibiotic loaded spacer leads to a comparable infection eradication rate, improved patient reported outcome and less complications compared to a prefabricated standard spacer
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- All authors
- Veltman, E.S.
- Supervisor
- Nelissen, R.G.H.H.; Poolman, R.W.
- Co-supervisor
- Mooijen, D.J.F.
- Committee
- Dijkstra, P.D.S.; Groenwold, R.H.H.; Jutte, P.C.; Wouthuyzen-Bakker, M.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Faculty of Medicine, Leiden University Medical Center (LUMC) , Leiden University
- Date
- 2020-12-09
- ISBN (print)
- 9789464210903