Leiden University Scholarly Publications

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Man, P.W. (2020)

Vitamin D relationships and genes of a Chinese population in the Netherlands

Doctoral Thesis
Vitamin D is essential for bone health. Vitamin D deficiency causes rickets and osteomalacia. In non-Western immigrants in the Netherlands, low vitamin D status is common. For example, low concentrations of 25-hydroxyvitamin D have been reported among Turkish, Moroccan, Surinamese, and sub-Saharan African populations. However, little is known about the vitamin D status of Chinese in the Netherlands. Therefore, this thesis aimed to determine the vitamin D status of a Chinese population in the Netherlands, and examined determinants of low 25-hydroxyvitamin D concentrations. Also, associations between 25-hydroxyvitamin D and bone, cardio-metabolic outcomes, and genetic factors were examined. Finally, a patient-friendly method to assess 25-hydroxyvitamin D concentration was investigated. The main result was that serum 25-hydroxyvitamin D concentration of our study population (42-46 nmol/L) appeared to be lower than that of ethnic Dutch (60-67 nmol/L), but better than other non...Show moreVitamin D is essential for bone health. Vitamin D deficiency causes rickets and osteomalacia. In non-Western immigrants in the Netherlands, low vitamin D status is common. For example, low concentrations of 25-hydroxyvitamin D have been reported among Turkish, Moroccan, Surinamese, and sub-Saharan African populations. However, little is known about the vitamin D status of Chinese in the Netherlands. Therefore, this thesis aimed to determine the vitamin D status of a Chinese population in the Netherlands, and examined determinants of low 25-hydroxyvitamin D concentrations. Also, associations between 25-hydroxyvitamin D and bone, cardio-metabolic outcomes, and genetic factors were examined. Finally, a patient-friendly method to assess 25-hydroxyvitamin D concentration was investigated. The main result was that serum 25-hydroxyvitamin D concentration of our study population (42-46 nmol/L) appeared to be lower than that of ethnic Dutch (60-67 nmol/L), but better than other non-Western immigrant groups in the Netherlands (24-38 nmol/L), as previously found by others. Almost one-quarter of our study population, however, did not meet the requirement for an adequate vitamin D status of the Health Council of the Netherlands (Gezondheidsraad). Therefore, public health authorities and health care providers should continue to make efforts to improve the vitamin D status of non-Western immigrants.
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25-Hydroxyvitamin D
Vitamin D status
Vitamin D deficiency
Bone mineral density
Chinese in the Netherlands
Non-Western immigrants
Non-skeletal outcomes
All authors
Man, P.W.
Supervisor
Middelkoop, B.J.C.; Lips, P.T.A.M.
Co-supervisor
Meer, I.M. van der
Committee
Kiefte-de Jong, J.C.; Reis, R.; Bouvy, M.L.; Appelman-Dijkstra, N.M.; Chel, V.G.M.; Schoor, N.M. van
Qualification
Doctor (dr.)
Awarding Institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Date
2020-12-08
ISBN (print)
9789463614405

Funding

Sponsorship
Stichting Artrose Zorg; Fonds voor het Hart; HOKIT Beheer B.V., onderdeel van Apotheek van Greuningen