Oxacarbenium ion intermediates in the stereoselective synthesis of anionic oligosaccharides

Dinkelaar, J. (2009)

Doctoral Thesis

In this thesis new strategies towards biologically active oligosaccharides are described. In addition a detailed mechanistic study is performed to investigate the stereodirecting capacity of glycosyl C-5 substituents in systems that were devoid of any other stereodirecting factors. The postulated mechanism described here can aid in the design of glycosylation strategies.

• Alginate
• Carbohydrates
• Hyaluronan
• Oligosaccharides
• Oxacarbenium ion
• Thioglycosides

• All authors: Dinkelaar, J.
• Supervisor: Marel, G.A. van der
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Science, Leiden University
• Date: 2009-05-13