Extracellular vesicle therapeutics for cardiac repair: A translational perspective

Mol, E.A. (2020)

Doctoral Thesis

This thesis describes the potential use of these cardiac progenitor-derived extracellular vesicles (EVs) for cardiac repair and focused on translational aspects that could accelerate clinical implementation of EV-based therapeutics. The first steps have been made in optimizing EV production processes such as EV isolation and storage. Furthermore, this thesis described a potential method for sustained EV release and to prolong therapeutic exposure by using a hydrogel. Ultimately, this could contribute to improved efficacy upon local delivery of EV therapeutics. Together, this thesis potentially contributes to fasten clinical adoption of EV-based therapeutics for patients with heart failure.

• Extracellular vesicles
• Exosomes
• Controlled release
• Injectable hydrogels
• Functionality
• Size-exclusion chromatography
• Ultracentrifugation
• Cardiac progenitor cell
• Cardiac repair

• All authors: Mol, E.A.
• Supervisor: Goumans, M.J.T.H.; Sluijter, J.P.G.
• Co-supervisor: Vader, P.
• Committee: Hoeben, R.C.; Atsma, D.E.; Zonneveld, A.J. van; Schiffelers, R.M.; Tryfonidou, M.A.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2020-10-07
• ISBN (print): 9789463808675
• Sponsorship: Hartstichting