Leiden University Scholarly Publications

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Paiman, E.H.M. (2020)

Phenotyping cardiometabolic disease with magnetic resonance techniques

Doctoral Thesis
Over the past decades, the number of individuals with type 2 diabetes has been growing worldwide. Type 2 diabetes is a major health concern, as it is related to several conditions, including heart failure and coronary artery disease. Despite remarkable advances in cardiovascular prevention and treatment, heart disease remains a common cause of death and an important contributor to health loss. The aim of this thesis was to characterize cardiovascular remodeling associated with metabolic disturbances, using a variety of magnetic resonance techniques. This thesis demonstrates that reduced diastolic function is a common characteristic of myocardial remodeling in type 2 diabetes and obesity, but also a potential marker for the detection of patients at increased cardiovascular risk after hematopoietic stem cell transplantation and possibly a contributing factor in the pathogenesis of ventricular arrhythmia after myocardial infarction. Also, in this thesis, it was...Show moreOver the past decades, the number of individuals with type 2 diabetes has been growing worldwide. Type 2 diabetes is a major health concern, as it is related to several conditions, including heart failure and coronary artery disease. Despite remarkable advances in cardiovascular prevention and treatment, heart disease remains a common cause of death and an important contributor to health loss. The aim of this thesis was to characterize cardiovascular remodeling associated with metabolic disturbances, using a variety of magnetic resonance techniques. This thesis demonstrates that reduced diastolic function is a common characteristic of myocardial remodeling in type 2 diabetes and obesity, but also a potential marker for the detection of patients at increased cardiovascular risk after hematopoietic stem cell transplantation and possibly a contributing factor in the pathogenesis of ventricular arrhythmia after myocardial infarction. Also, in this thesis, it was shown that the evaluation of visceral adiposity and myocardial triglyceride content may help to identify distinct cardiometabolic phenotypes and to better understand the cardiometabolic actions of the glucagon-like peptide 1 receptor agonist liraglutide. With the emergence of non-contrast cardiovascular protocols, magnetic resonance techniques may be increasingly used for cardiometabolic phenotyping in population-based cohorts as well as clinical studies.Show less
Diabetic Cardiomyopathy
Type 2 Diabetes
Obesity
Glucagon-like Peptide 1 Receptor Agonist
Left Ventricular Diastolic Dysfunction
Myocardial Proton-Magnetic Resonance Spectroscopy
Cardiac T1 Mapping
Myocardial Tissue Characterization
All authors
Paiman, E.H.M.
Supervisor
Lamb, H.J.
Co-supervisor
Geest, R.J. van der; Jazet, I.M.
Committee
Planken, R.N.; Middeldorp, S.; Pijl, H.
Qualification
Doctor (dr.)
Awarding Institution
Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
Date
2020-10-01
ISBN (print)
9789463614498

Funding

Sponsorship
Cardio Vascular Imaging Group (CVIG), Leiden, the Netherlands NWO Domain Applied and Engineering Sciences, grant number 12899 Novo Nordisk A/S, Bagsvaerd, Denmark