Applications of the tumor-stroma ratio: Towards clinical implementation

Pelt, G.W. van (2020)

Doctoral Thesis

This thesis describes the detailed method of scoring the tumor-stroma ratio and the different possibilities to use it in routine clinical diagnostics, for different types of cancer. It can be used not only for prognostic purposes, but it might also be useful for predicting the response on neo-adjuvant therapy. As it is an easy and cheap method, based on routine hematoxylin-eosin stained tissue slides used for daily pathology routine, it can be implemented in clinical diagnostics with little effort.

• Tumor-stroma ratio
• Tumor microenvironment
• Colon cancer
• Prognosis
• Prediction
• Lymph nodes

• All authors: Pelt, G.W. van
• Supervisor: Tollenaar, R.A.E.M.; Krieken, J.H.J.M. van
• Co-supervisor: Mesker, W.E.
• Committee: Geus-Oei, L.F. de; Borel Rinkens, I.H.M.; Snaebjornsson, P.; Liefers, G.J.; Gelderblom, A.J.; Kjær-Frifeldt, S.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2020-09-30
• ISBN (print): 9789463758017