Generation of antigen-specific T cell immunity through T cell receptor gene transfer

Coccoris, M. (2009)

Doctoral Thesis

Cancer cells often escape the attack of immune cells because they originate from self-tissue. Through T cell receptor gene transfer it is possible to equip peripheral T cells with a desired specificity, and this strategy may be useful to generate tumor-specific T cells for the treatment of cancer in humans. This thesis describes several aspects in the functionality, safety and longevity of T cells modified by T cell receptor gene transfer in animal models.

• T cell receptor
• Gene transfer
• Adoptive transfer

• All authors: Coccoris, M.
• Supervisor: Schumacher, T.N.M.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2009-01-21