Lifestyle and venous thrombosis

Pomp, E.R. (2008)

Doctoral Thesis

In the Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis (MEGA study), a large population-based case-control study, we investigated lifestyle factors as risk factors for venous thrombosis. Overweight, smoking and alcohol consumption were addressed and pregnancy and the postpartum period were evaluated in women. Due to the large sample size of the study it was possible to investigate the joint effect of these risk factors with important genetic risk factors for venous thrombosis such as the factor V Leiden and the prothrombin 20210A mutation. In addition to these lifestyle related risk factors, two polymorphisms within the promoter region of the protein C gene were studied as risk factors for venous thrombosis and the influence of genotypic variation on plasma protein C levels was assessed. Finally, we described our experience with the inclusion of two different control groups in the MEGA study.

• Alcohol consumption
• Case-control study
• Factor V Leiden mutation
• Multiple control groups
• Obesity
• Pregnancy
• Protein C polymorphisms
• Prothrombin 20210A mutation
• Smoking
• Venous thrombosis

• All authors: Pomp, E.R.
• Supervisor: Rosendaal, F.R.
• Co-supervisor: Doggen, C.J.M.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2008-12-03
• ISBN (print): 9789085594550
• Sponsorship: The Netherlands Heart foundation J.E. Jurriaanse Stichting