ABC-transporters and lipid transfer proteins : important players in macrophage cholesterol homeostasis and atherosclerosis

Ye, D. (2008)

Doctoral Thesis

Local modulation of macrophage cholesterol metabolism in the arterial wall and systemic regulation of lipoprotein metabolism (LDL-lowering and/or HDL-raising) are both attractive targets for future drug design for the prevention of atherosclerosis. As described in this thesis, bone marrow transplantation can be considered a useful strategy to study the role of macrophage-expressing genes and gene products in lipoprotein metabolism and atherogenesis, which may lead to the identification of target genes for pharmaceutical interventions.

• ABC-transporters
• atherosclerosis
• Lipid transfer proteins

• All authors: Ye, D.
• Supervisor: Berkel, T.J. van
• Co-supervisor: Eck, M. van
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2008-11-04
• ISBN (print): 9789074538688
• Sponsorship: The thesis was financially supported by the Chinese Scholarship Council. Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.