Search for new breast cancer susceptibility genes

Oldenburg, R.A. (2008)

Doctoral Thesis

This thesis describes the search for new high-risk breast cancer susceptibility genes by linkage analysis. To date 20-25% of familial breast cancer is explained by mutations in the high-risk BRCA1 and BRCA2 breast cancer susceptibility genes. For the remaining families the genetic etiology is unknown. It is still possible that other high-penetrant genes play a role. Although a polygenic model with multiple low-penetrant genes acting additive or multiplicative will probable explain most of the BRCA1/2 negative families. Linkage in an international set of 150 high-risk breast cancer families couldn__t identify high-risk genes. However when limiting the linkage analysis to Dutch families only, we identified 9q21-22 as a putative breast cancer susceptibility locus

• Genetics
• Breast cancer
• Immunohistochemistry
• CGH
• Linkage Analysis
• Heterogeneity

• All authors: Oldenburg, R.A.
• Supervisor: Devilee, P.; Meijers-Heijboer, E.J.; Cornelisse, C.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2008-05-29
• Sponsorship: The Dutch Cancer Society