Adoptive transfer of tumor- and minor antigen-specific T cell reactivity in mouse models

Witte, M.A. de (2008)

Doctoral Thesis

Adoptive transfer of T cell immunity has been proposed as an attractive form of cancer immunotherapy in cases where the endogenous T cell repertoire is immune tolerant. In this thesis murine models are used to study two different approaches to generate T cell grafts with defined tumor specificities. First the feasibility of minor antigen specific T cell depletion to limit the development of Graft-versus-Host Disease after allogeneic stem cell transplantation in combination with donor lymphocyte infusions is addressed. In the second part T cell receptor gene transfer is used to generate tumor specific T cells.

• Allogeneic stemcell transplantation
• Gene therapy
• Graft-versus-Host Disease
• Immunotherapy
• Minor antigen
• TCR gene transfer

• All authors: Witte, M.A. de
• Supervisor: Schumacher, T.N.M.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2008-05-29
• Sponsorship: Stichting AMSTOL, BD Biosciences, Corning BV