Cardiac bone marrow cell injection for chronic ischemic heart disease

Beeres, S.L.M.A. (2007)

Doctoral Thesis

The aim of this thesis was to evaluate the safety, feasibility and potential efficacy of autologous bone marrow mononuclear cell injection in patients with chronic ischemic heart disease. For this purpose, 30-100 million autologous bone marrow cells were injected into the ischemically-damaged myocardium of 50 patients with chronic ischemic heart disease. The results of the current studies demonstrate that intramyocardial injection of autologous bone marrow mononuclear cells in patients with chronic ischemic heart disease is feasible and safe. In particular, the electrophysiological properties of the injected myocardium remain unchanged and aggravation of coronary atherosclerosis is not observed. Moreover, autologous bone marrow cell injection seems to be associated with a beneficial effect on anginal symptoms, myocardial perfusion and left ventricular (systolic and diastolic) function. The beneficial effects of cardiac cell therapy appear to be sustained over a longer period of follow-up.

• Ischemic heart disease
• Bone marrow cells
• Anginal symptoms
• Left ventricular function
• Myocardial perfusion

• All authors: Beeres, S.L.M.A.
• Supervisor: Schalij, M.J.; Bax, J.J.
• Co-supervisor: Atsma, D.E.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University Medical Center (LUMC), Leiden University
• Date: 2007-10-17
• Publisher: Department of Cardiology, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• ISBN (print): 9789090222110