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Hazekamp, A. (2007)

Cannabis: extracting the medicine

Doctoral Thesis
The cannabis plant (Cannabis sativa L.) has a long history as a recreational drug, but also as part of traditional medicine in many cultures. Nowadays, it is used by a large number of patients worldwide, to ameliorate the symptoms of diseases varying from cancer and AIDS to multiple sclerosis and migraine. The discovery of cannabinoid-receptors and the endocannabinoid system have opened up a new and exciting field of research. But despite the pharmaceutical potential of cannabis, its classification as a narcotic drug has prevented the successful development of cannabis into modern medicine. Although a huge number of scientific papers has been published on cannabis, there is currently no scientific consensus on the usefulness of medicinal cannabis. In 2004, The Netherlands became the first country to make herbal cannabis available as a prescription drug. The phytochemical research presented in this thesis has been possible because of the availability of these high-grade cannabis...Show moreThe cannabis plant (Cannabis sativa L.) has a long history as a recreational drug, but also as part of traditional medicine in many cultures. Nowadays, it is used by a large number of patients worldwide, to ameliorate the symptoms of diseases varying from cancer and AIDS to multiple sclerosis and migraine. The discovery of cannabinoid-receptors and the endocannabinoid system have opened up a new and exciting field of research. But despite the pharmaceutical potential of cannabis, its classification as a narcotic drug has prevented the successful development of cannabis into modern medicine. Although a huge number of scientific papers has been published on cannabis, there is currently no scientific consensus on the usefulness of medicinal cannabis. In 2004, The Netherlands became the first country to make herbal cannabis available as a prescription drug. The phytochemical research presented in this thesis has been possible because of the availability of these high-grade cannabis plants. This thesis has a specific focus on the cannabinoids and on analytical problems that currently obstruct advanced study of the cannabis plant. Furthermore, it deals with much needed methods for quality control and with administration forms of medicinal cannabis. In general, it may be considered a general guidebook, covering all the basic phytochemical aspects of medicinal cannabis.Show less
Administration forms
Cannabinoids
Cannabis
Chromatography
Herbal medicine
Phytochemistry
Quality control
Tetrahydrocannabinol (THC)
All authors
Hazekamp, A.
Supervisor
Verpoorte, R.
Committee
Giroud, C.; Danhof, M.; Hondel, C.A.M.J.J. van den; Scheffer, J.J.C.; Heijden, R. van der
Qualification
Doctor (dr.)
Awarding Institution
Institute of Biology Leiden (IBL), Faculty of Science, Leiden University
Date
2007-09-05
ISBN (print)
9789090219974

Juridical information

Court
LEI Universiteit Leiden

Funding

Sponsorship
Grafisch Papier Nijmegen BV, The Netherlands Storz & Bickel GmbH & Co. KG, Tuttlingen, Germany Farmalyse BV, Zaandam, The Netherlands Nationaal MS-fonds, Maassluis, The Netherlands Multidisciplinary Association for Psychedelic Studies (MAPS), California, USA Bedrocan BV, Veendam, The Netherlands Mr. Michael Sautman, California, USA