AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm

Heer, F. de; Kluin, J.; Elkhoury, G.; Jondeau, G.; Enriquez-Sarano, M.; Schafers, H.J.; ... ; Aortic Valve Repair Res Network In (2019)

Article / Letter to editor

Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included.Methods: The AV repair research network includes surgeons, cardiologists, and scientists and established an online database compliant with the guidelines for reporting valve-related events. Prospective inclusion started from January 2013. Adult patients (18 years or older) who were operated on between 1995 and 2017 with complete procedural specification of the type of repair/replacement were selected for descriptive analysis.Results: Currently 58 centers from 17 countries include 4896 patients with 89% AV repair (n = 4379) versus 11% AV replacement (n = 517). AV repair was either isolated (28%), or associated with tubular/partial root replacement (22%) or valve-sparing root replacement (49%) with an in-hospital mortality of 0.5%, 1.7%, and 1.2%, respectively. AV replacement was either isolated (24%), associated with tubular/partial root replacement (17%) or root replacement (59%) with an in-hospital mortality of 1%, 2.6%, and 2.0%, respectively.Conclusions: The multicenter surgical AVIATOR registry, by applying uniform definitions, should provide a solid evidence base to evaluate the place of repair versus replacement on the basis of long-term patient outcomes. Obtaining data completeness and adequate representation of all surgery types remain challenging. Toward the near future AVIATOR-medical will start to study natural history, as will AVIATOR-kids, with a focus on pediatric disease.

• aortic valve regurgitation
• ascending aortic aneurysm
• valve surgery
• outcome analysis
• international registry
• long-term echocardiographic follow-up

• All authors: Heer, F. de; Kluin, J.; Elkhoury, G.; Jondeau, G.; Enriquez-Sarano, M.; Schafers, H.J.; Takkenberg, J.J.M.; Lansac, E.; Dinges, C.; Steindl, J.; Ziller, R.; Kerchove, L. de; Benkacem, T.; Coulon, C.; Kaddouri, F.; Vanoverschelde, J.L.; Meester, C. de; Pasquet, A.; Nijs, J.; Mosselvelde, V. van; Loeys, B.; Meuris, B.; Schepmans, E.; Bossche, K. van den; Verbrugghe, P.; Goossens, W.; Gutermann, H.; Pettinari, M.; El-Hamamsy, I.; Lenoir, M.; Noly, P.E.; Tousch, M.; Shah, P.; Boodhwani, M.; Rudez, I.; Baric, D.; Unic, D.; Varvodic, J.; Gjorgijevska, S.; Vojacek, J.; Zacek, P.; Karalko, M.; Hlubocky, J.; Novotny, R.; Slautin, A.; Soliman, S.; Arnaud-Crozat, E.; Boignard, A.; Fayad, G.; Bouchot, O.; Albat, B.; Leguerrier, A.; Doguet, F.; Fuzellier, J.F.; Glock, Y.; Fernandez, G.; Chatel, D.; Zeitoun, D.M.; Jouan, J.; Centa, I. di; Obadia, J.F.; Leprince, P.; Houel, R.; Bergoend, E.; Lopez, S.; Berrebi, A.; Lejeune, S.; Monin, J.L.; Pousset, S.; Tubach, F.; Mankoubi, L.; Noghin, M.; Diakov, C.; Czytrom, D.; Theisohn, F.; Aicher, D.; Borger, M.; Ferrero, P.; Stoica, S.; Matuszewski, M.; Yiu, P.; Bashir, M.; Ceresa, F.; Patane, F.; Paulis, R. de; Chirichilli, I.; Masat, M.; Antona, C.; Contino, M.; Mangini, A.; Romagnoni, C.; Rosa, R.; Grigioni, F.; Okita, Y.; Miyairi, T.; Kunihara, T.; Gokalp, A.; Marsman, M.; Koolbergen, D.; Bekkers, J.; Duininck, L.; Arabkhani, B.; Brakel, T. van; Klautz, R.; Mecozzi, G.; Accord, R.; Jasinski, M.; Aminov, V.; Svetkin, M.; Kolesar, A.; Sabol, F.; Toporcer, T.; Bibiloni, I.; Rabago, G.; Alvarez-Asiain, V.; Melero, A.; Sadaba, R.; Aramendi, J.; Crespo, A.; Porras, C.; Masip, A.E.; Bavaria, J.; Milewski, R.; Moeller, P.; Wenger, I.; Alger, S.; Alger, A.; Kelley, S.; Leavitt, K.; Aortic Valve Repair Res Network In
• Date: 2019-06-01
• Journal: The Journal of Thoracic and Cardiovascular Surgery
• Volume: 157
• Issue: 6
• Pages: 2202 - +
• DOI: doi:10.1016/j.jtcvs.2018.10.076