Fc Receptor Type I (CD64)-Mediated Impairment of the Capacity of Dendritic Cells to Activate Specific CD8 T Cells by IgG-opsonized Friend Virus

Banki, Z.; Werner, R.; Riepler, L.; Rossler, A.; Mullauer, B.; Hegen, V.; ... ; Stoiber, H. (2019)

Article / Letter to editor

Dendritic cells (DCs) express Fc receptors (FcRs) for the binding immune complexes (ICs) consisting of IgG and antigens (Ags). IC-FcR interactions have been demonstrated to enhance activation and antigen-presenting functions of DCs. Utilizing Friend virus (FV), an oncogenic mouse retrovirus, we investigated the effect of IgG-opsonization of retroviral particles on the infection of DCs and the subsequent presentation of viral antigens by DCs to virus-specific CD8 T cells. We found that opsonization by virus-specific non-neutralizing IgG abrogated DC infection and as a consequence significantly reduced the capacity of DCs to activate virus-specific CD8 T cells. Effects of IgG-opsonization were mediated by the high-affinity FcR type I, CD64, expressed on DCs. Our results suggest that different opsonization patterns on the retroviral surface modulate infection and antigen-presenting functions of DCs, whereby, in contrast to complement, IgG reduces the capacity of DCs to activate cytotoxic T cell (CTL) responses.

• friend virus
• dendritic cells
• IgG-opsonization
• Fc receptors
• CD8 T cells

• All authors: Banki, Z.; Werner, R.; Riepler, L.; Rossler, A.; Mullauer, B.; Hegen, V.; Bayer, W.; Verbeek, J.S.; Dittmer, U.; Stoiber, H.
• Date: 2019-02-01
• Journal: Viruses
• Volume: 11
• Issue: 2
• DOI: doi:10.3390/v11020145