Longitudinal quantitative assessment of coronary plaque progression related to body mass index using serial coronary computed tomography angiography

Won, K.B.; Lee, S.E.; Lee, B.K.; Park, H.B.; Heo, R.; Rizvi, A.; Hadamitzky, M.; Kim, Y.J.; Sung, J.M.; Conte, E.; Andreini, D.; Pontone, G.; Budoff, M.J.; Gottlieb, I.; Chun, E.J.; Cademartiri, F.; Maffei, E.; Marques, H.; Leipsic, J.A.; Shin, S.; Choi, J.H.; Virmani, R.; Samady, H.; Stone, P.H.; Berman, D.S.; Narula, J.; Shaw, L.J.; Bax, J.J.; Min, J.K.; Chang, H.J.

doi:doi:10.1093/ehjci/jey192

Aims This study explored the coronary plaque volume change ( PVC) according to the change of percent body mass index (BMI) and categorical BMI group using serial coronary computed tomography angiography (CCTA).Methods and results A total of 1568 subjects who underwent serial CCTA with available BMI at baseline (CCTA1) and follow-up (CCTA2) were included. Median inter-scan period was 3.3 (interquartile range: 2.6-4.6) years. Quantitative assessment of coronary plaque was performed at both scans. All participants were categorized into three BMI (kg/m(2)) groups: normal: <25.0; overweight: 25.0-29.9; and obesity: >= 30.0. During follow-up, there were no significant differences in annualized PVC according to the 5% change of BMI in all BMI groups. Among 1424 (90.8%) subjects in the same BMI group at CCTA1 and CCTA2, a significant difference in annualized (PVC) was observed among the three groups. In 144 (9.2%) subjects with the change in their BMI group at CCTA2 compared their results...Show moreAims This study explored the coronary plaque volume change ( PVC) according to the change of percent body mass index (BMI) and categorical BMI group using serial coronary computed tomography angiography (CCTA).Methods and results A total of 1568 subjects who underwent serial CCTA with available BMI at baseline (CCTA1) and follow-up (CCTA2) were included. Median inter-scan period was 3.3 (interquartile range: 2.6-4.6) years. Quantitative assessment of coronary plaque was performed at both scans. All participants were categorized into three BMI (kg/m(2)) groups: normal: <25.0; overweight: 25.0-29.9; and obesity: >= 30.0. During follow-up, there were no significant differences in annualized PVC according to the 5% change of BMI in all BMI groups. Among 1424 (90.8%) subjects in the same BMI group at CCTA1 and CCTA2, a significant difference in annualized (PVC) was observed among the three groups. In 144 (9.2%) subjects with the change in their BMI group at CCTA2 compared their results at CCTA1, annualized PVC was not different compared with subjects in the same BMI group during follow-up. The percent change of BMI was not significantly related to the annualized PVC after adjusting confounding factors. Male gender [odds ratio (OR): 1.38; 95% confidence interval (CI): 1.05-1.81; P=0.022], baseline plaque volume (OR: 1.07; 95% CI: 1.05-1.09; P<0.001), and baseline overweight or obesity (OR: 1.35; 95% CI: 1.04-1.77; P=0.027) were independently associated with coronary plaque progression.Conclusion Over the near term, longitudinal small changes in BMI were not associated with changes in coronary plaque volume although baseline BMI was.Show less

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Longitudinal quantitative assessment of coronary plaque progression related to body mass index using serial coronary computed tomography angiography