A MRI study into the effect of pravastatin on cerebrovascular pathologies

Dam, V.H. ten (2007)

Doctoral Thesis

Aging of the brain was studied by comparing follow-up MRI scans in 554 persons aged 70-82 years. Mean interval time between these scans was three years and scans were looked for changes in cerebral infarcts, white matter lesions, cerebral blood flow, and brain volume. Besides this, the preventive effect of pravastatin on these changes was studied. During the study time there was progression of cerebral infarcts, white matter lesions and there was decline of cerebral blood flow and progression of brain atrophy. Treatment with pravastatin 40 mg/daily did not have a protective effect on these changes.

• Brain atrophy
• Cerebral blood flow
• Cerebral infarcts
• Elderly
• MRI
• Periventricular white matter lesions
• Statins
• White matter lesions

• All authors: Dam, V.H. ten
• Supervisor: Westendorp, R.G.J.; Buchem, M.A. van
• Co-supervisor: Blauw, G.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Department Geriatrics and Gerontology, Department Radiology, Leiden University Medical Center (LUMC), Leiden University
• Date: 2007-06-21
• ISBN (print): 9789090219080
• Court: LEI Universiteit Leiden