Leiden University Scholarly Publications

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Siebenga, P.S.; Amerongen, G. van; Okkerse, P.; Denney, W.S.; Dua, P.; Butt, R.P.; ... ; Groeneveld, G.J. (2019)

Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

Article / Letter to editor
BACKGROUND: Although reproducibility is considered essential for any method used  in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain models involving  human subjects. Here, we studied the reproducibility of a battery of evoked pain  models for demonstrating the analgesic effects of two analgesic compounds. METHODS: A total of 81 healthy subjects participated in four studies involving a  battery of evoked pain tests in which mechanical, thermal and electrical stimuli  were used to measure pain detection and tolerance thresholds. Pharmacodynamic outcome variables were analysed using a mixed model analysis of variance, and a coefficient of variation was calculated by dividing the standard deviation by the least squares means. RESULTS: A total of 76 subjects completed the studies. After being administered pregabalin, the subjects' pain tolerance thresholds in the cold pressor and pressure...Show moreBACKGROUND: Although reproducibility is considered essential for any method used  in scientific research, it is investigated only rarely; thus, strikingly little has been published regarding the reproducibility of evoked pain models involving  human subjects. Here, we studied the reproducibility of a battery of evoked pain  models for demonstrating the analgesic effects of two analgesic compounds. METHODS: A total of 81 healthy subjects participated in four studies involving a  battery of evoked pain tests in which mechanical, thermal and electrical stimuli  were used to measure pain detection and tolerance thresholds. Pharmacodynamic outcome variables were analysed using a mixed model analysis of variance, and a coefficient of variation was calculated by dividing the standard deviation by the least squares means. RESULTS: A total of 76 subjects completed the studies. After being administered pregabalin, the subjects' pain tolerance thresholds in the cold pressor and pressure stimulation tests were significantly increased compared to the placebo group. Moreover, the heat pain detection threshold inShow less
All authors
Siebenga, P.S.; Amerongen, G. van; Okkerse, P.; Denney, W.S.; Dua, P.; Butt, R.P.; Hay, J.L.; Groeneveld, G.J.
Date
2019
Journal
European Journal of Pain
DOI
doi:10.1002/ejp.1379