Leiden University Scholarly Publications

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Albers, H.M.; Brinkman, D.M.C.; Kamphuis, S.S.M.; Suijlekom-Smit, L.W.A. van; Rossum, M.A.J. van; Hoppenreijs, E.P.A.H.; ... ; Cate, R. ten (2010)

Clinical course and prognostic value of disease activity in the first two years in different subtypes of juvenile idiopathic arthritis

Article / Letter to editor
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is a heterogeneous disease involving chronic arthritis. The clinical course is characterized by a fluctuating pattern of active and inactive disease. We have described in detail the clinical course in different JIA subtypes during the first 2 years after diagnosis and studied its relationship to disease activity in the following years. METHODS: Detailed clinical data on different parameters describing the disease activity in sequential time periods covering the first 2 years after diagnosis were retrieved from the charts of 311 patients with JIA and compared between subtypes. In a cohort of 146 patients, the relation of these different clinical variables to the course of disease in the following 3 years was evaluated. RESULTS: The percentage of time with active disease in the first 2 years differed significantly between subtypes. In all subtypes, a broad spectrum of activity was observed. The time with active disease in the first 2...Show moreOBJECTIVE: Juvenile idiopathic arthritis (JIA) is a heterogeneous disease involving chronic arthritis. The clinical course is characterized by a fluctuating pattern of active and inactive disease. We have described in detail the clinical course in different JIA subtypes during the first 2 years after diagnosis and studied its relationship to disease activity in the following years. METHODS: Detailed clinical data on different parameters describing the disease activity in sequential time periods covering the first 2 years after diagnosis were retrieved from the charts of 311 patients with JIA and compared between subtypes. In a cohort of 146 patients, the relation of these different clinical variables to the course of disease in the following 3 years was evaluated. RESULTS: The percentage of time with active disease in the first 2 years differed significantly between subtypes. In all subtypes, a broad spectrum of activity was observed. The time with active disease in the first 2 years was the most significant factor associated with the duration of active disease in the following years. CONCLUSION: Different percentages of time with active disease have been observed between JIA subtypes in the first 2 years. The cumulative duration of activity varied widely within each subtype. Regarding the prognosis of the individual patient, the clinical course in the first 2 years appears to be predictive of the clinical course in the following years. Patients that have less time with active disease in the first 2 years are not likely to develop an unremitting clinical course later on.Show less
All authors
Albers, H.M.; Brinkman, D.M.C.; Kamphuis, S.S.M.; Suijlekom-Smit, L.W.A. van; Rossum, M.A.J. van; Hoppenreijs, E.P.A.H.; Girschick, H.J.; Wouters, C.; Saurenmann, R.K.; Houwing-Duistermaat, J.J.; Huizinga, T.W.J.; Schilham, M.W.; Cate, R. ten
Date
2010-02-28
Volume
62
Issue
2
Pages
204 - 12
DOI
doi:10.1002/acr.20069