Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas

Trietsch, M.D.; Oonk, M.H.M.; Hawinkels, L.J.A.C.; Bor, R.; Eendenburg, J.D.H. van; Ivanova, Z.; ... ; Bosse, T. (2016)

Article / Letter to editor

Conclusion: This is the first study to show high L1CAM-expression at the infiltrating margin of VSCC's. L1CAM-expressing VSCCs had a significantly worse prognosis compared to L1CAM-negative tumours. The highest expression was observed in spindle-shaped cells, where it might be correlated to their invasive capacity.

• L1 cell adhesion molecule
• L1CAM
• vulvar cancer
• squamous cell carcinoma
• survival

• All authors: Trietsch, M.D.; Oonk, M.H.M.; Hawinkels, L.J.A.C.; Bor, R.; Eendenburg, J.D.H. van; Ivanova, Z.; Peters, A.A.W.; Nijman, H.W.; Gaarenstroom, K.N.; Bosse, T.
• Date: 2016-05-03
• Journal: Oncotarget
• Volume: 7
• Issue: 18
• Pages: 26192 - 26205
• DOI: doi:10.18632/oncotarget.8353