Plasma copeptin as biomarker of disease progression and prognosis in cirrhosis

Sola, E.; Kerbert, A.J.C.; Verspaget, H.W.; Moreira, R.; Pose, E.; Ruiz, P.; ... ; Gines, P. (2016)

Article / Letter to editor

Lay summary: Copeptin is a fragment of the vasopressin precursor, a hormone that is known to be increased in patients with cirrhosis and that plays a role in the development of complications of the disease. Vasopressin is difficult to measure, but copeptin is a more stable molecule and is easier to measure in blood. Sola and Kerbert and colleagues have shown in a series of 361 patients that copeptin is markedly increased in patients with cirrhosis who develop complications during the following 3 months, compared to those patients who do not develop complications. Moreover, copeptin correlates with prognosis. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

• Copeptin
• Biomarker
• Cirrhosis
• Circulatory dysfunction
• Prognosis

• All authors: Sola, E.; Kerbert, A.J.C.; Verspaget, H.W.; Moreira, R.; Pose, E.; Ruiz, P.; Cela, R.; Morales-Ruiz, M.; Lopez, E.; Graupera, I.; Sole, C.; Huelin, P.; Navarro, A.A.; Ariza, X.; Jalan, R.; Fabrellas, N.; Benten, D.; Prada, G. de; Durand, F.; Jimenez, W.; Reijden, J.J. van der; Fernandez, J.; Hoek, B. van; Coenraad, M.J.; Gines, P.
• Date: 2016-11-01
• Journal: Journal of Hepatology
• Volume: 65
• Issue: 5
• Pages: 914 - 920
• DOI: doi:10.1016/j.jhep.2016.07.003